Proton-transporting two-sector ATPase complex assembly

Across TCGA patient cohorts, RNA activity of the Proton-transporting two-sector ATPase complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPAG7, ZFHX3_S3432, and TRIM28, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proton-transporting two-sector ATPase complex assembly activity versus SPAG7 in UCEC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPAG7 →	+0.272	+0.047	<.001	<.001	3	5
OV	ZFHX3_S3432 →	+0.732	+0.028	<.001	.001	3	5
GBM	TRIM28 →	-0.349	-0.049	.002	<.001	3	5
LSCC	MLKL →	-0.385	-0.041	.003	.002	3	5
LSCC	IMPACT_S297 →	+0.632	+0.036	.001	<.001	3	4
LSCC	MSH6 →	+0.509	+0.040	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070071 vs SPAG7 — UCEC

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