Proton-transporting two-sector ATPase complex assembly

Across TCGA cell cohorts, RNA activity of the Proton-transporting two-sector ATPase complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERAP1, MICALL1, and APRT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proton-transporting two-sector ATPase complex assembly activity versus ERAP1 in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ERAP1 →	+2.233	+0.322	.002	.002	3	5
PANCREAS	MICALL1 →	+1.195	+0.201	.002	.001	3	4
SOFT_TISSUE	APRT →	-0.772	-0.265	.001	<.001	3	4
STOMACH	ACTB →	+0.930	+0.245	.002	.004	3	4
PANCREAS	BLCAP →	+1.502	+0.199	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TNIP2 →	-0.565	-0.172	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070071 vs ERAP1 — BONE

Explore this scatter interactively →