Proton-transporting V-type ATPase complex assembly

Across TCGA patient cohorts, RNA activity of the Proton-transporting V-type ATPase complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP18_S205, WDR36, and CDK7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proton-transporting V-type ATPase complex assembly activity versus UTP18_S205 in PDAC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	UTP18_S205 →	-0.497	-0.059	.001	.002	3	6
GBM	WDR36 →	-0.207	-0.060	.001	<.001	3	6
PDAC	CDK7 →	-0.192	-0.067	.001	<.001	3	6
GBM	USP39 →	-0.270	-0.053	<.001	<.001	3	6
LUAD	DDX21_S89 →	-0.808	-0.048	<.001	<.001	3	6
LUAD	NUP88_S517 →	-0.441	-0.046	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070070 vs UTP18_S205 — PDAC

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