Proton-transporting V-type ATPase complex assembly

Across TCGA cell cohorts, RNA activity of the Proton-transporting V-type ATPase complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JKAMP, AXL, and AZIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JKAMP grouped by Proton-transporting V-type ATPase complex assembly-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	JKAMP →	-0.742	-1.567	<.001	<.001	3	5
OVARY	AXL →	-2.884	-1.125	<.001	<.001	3	4
PANCREAS	AZIN1 →	-0.550	-0.944	.006	.003	3	4
BONE	IQGAP2 →	+2.292	+1.318	.003	.008	3	4
BONE	CFAP161 →	+0.928	+1.452	.008	.004	3	3
SOFT_TISSUE	GDF9 →	+0.213	+1.307	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JKAMP by Proton-transporting V-type ATPase complex assembly activity — OVARY

Explore this box plot interactively →