Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK11, COPZ2, and DOCK10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress activity versus DOCK11 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOCK11 →	+0.502	+0.031	<.001	<.001	3	9
OV	COPZ2 →	+0.792	+0.032	<.001	<.001	3	8
LSCC	DOCK10 →	+0.446	+0.063	<.001	<.001	3	8
LSCC	LPXN →	+0.470	+0.049	<.001	<.001	3	8
GBM	AMPD3 →	+0.503	+0.039	<.001	<.001	3	7
GBM	ARHGAP9 →	+0.441	+0.026	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070059 vs DOCK11 — OV

Explore this scatter interactively →