Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Across TCGA cell cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINE1, MICALL1, and CGN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERPINE1 grouped by Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SERPINE1 →	-4.473	-0.913	.002	.006	3	6
CNS	MICALL1 →	-1.022	-1.237	.002	<.001	3	6
BREAST	CGN →	+1.469	+0.736	.006	.003	3	4
LUNG_NSCLC_LUSC	IKBIP →	-1.542	-0.949	.002	.004	3	4
SKIN	HDDC3 →	+0.434	+1.035	.008	<.001	3	4
OVARY	CD59 →	-1.454	-1.267	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERPINE1 by Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →