Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Across TCGA cell cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADORA2B, PLPP2, and NUDT16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress activity versus ADORA2B in BREAST (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ADORA2B →	+2.037	+0.196	.001	.005	3	4
SOFT_TISSUE	PLPP2 →	+3.618	+0.129	<.001	.008	3	4
BLOOD_Leukemia	NUDT16 →	-1.282	-0.143	<.001	.006	3	4
LUNG_SCLC	PXYLP1 →	+0.989	+0.148	.003	.007	3	4
STOMACH	CDK2AP1 →	-0.817	-0.176	.004	.004	3	4
STOMACH	DAPK1 →	+2.321	+0.165	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070059 vs ADORA2B — BREAST

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