Neuron cellular homeostasis

Across TCGA patient cohorts, RNA activity of the Neuron cellular homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PBRM1, ARHGEF5, and PSIP1_S275, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron cellular homeostasis activity versus PBRM1 in GBM (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PBRM1 →	-0.312	-0.044	.001	<.001	3	5
UCEC	ARHGEF5 →	+0.322	+0.041	<.001	.001	3	5
LSCC	PSIP1_S275 →	-0.801	-0.049	.001	<.001	3	5
HNSC	ZKSCAN8_S193 →	-0.606	-0.043	<.001	.008	3	5
LSCC	CHD3_T1569 →	-0.440	-0.041	.002	.002	3	5
LSCC	HSPB1 →	+0.712	+0.055	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070050 vs PBRM1 — GBM

Explore this scatter interactively →