Neuron cellular homeostasis

Across TCGA patient cohorts, RNA activity of the Neuron cellular homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC11A, SEPTIN4, and CNRIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron cellular homeostasis activity versus CLEC11A in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLEC11A →	+0.802	+0.205	.001	<.001	3	5
GBM	SEPTIN4 →	+1.350	+0.459	<.001	<.001	3	5
BRCA	CNRIP1 →	+0.584	+0.155	<.001	<.001	3	5
HNSC	CDH11 →	+0.738	+0.174	.001	.001	3	5
BRCA	LMOD1 →	+0.889	+0.157	<.001	<.001	3	5
GBM	EDIL3 →	+1.713	+0.432	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070050 vs CLEC11A — BRCA

Explore this scatter interactively →