Protein-DNA complex assembly

Across TCGA cell cohorts, RNA activity of the Protein-DNA complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL3, CCDC138, and EIF2S2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL3 grouped by Protein-DNA complex assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARL3 →	-1.244	-0.305	<.001	.002	3	5
LIVER	CCDC138 →	-0.713	-0.252	.009	.001	3	5
BREAST	EIF2S2 →	-0.762	-0.165	.002	<.001	3	4
LUNG_NSCLC_LUSC	ZNF300 →	-2.503	-0.291	.005	.004	2	5
LUNG_NSCLC_LUSC	ZNF30 →	-0.805	-0.282	.003	.003	3	4
LUNG_NSCLC_LUSC	SKIDA1 →	-0.614	-0.247	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL3 by Protein-DNA complex assembly activity — STOMACH

Explore this box plot interactively →