Protein-DNA complex assembly

Across TCGA cell cohorts, RNA activity of the Protein-DNA complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCC, H1-10, and CBX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-DNA complex assembly activity versus FANCC in BONE (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FANCC →	+0.856	+0.266	.002	.009	3	6
SKIN	H1-10 →	+0.931	+0.127	<.001	.001	3	5
BREAST	CBX2 →	+1.490	+0.254	.002	<.001	3	5
LUNG_SCLC	CNIH2 →	+1.782	+0.128	.001	.004	3	5
LUNG_SCLC	OXLD1 →	-0.616	-0.110	.001	.004	3	5
URINARY_TRACT	OCEL1 →	-1.099	-0.257	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0065004 vs FANCC — BONE

Explore this scatter interactively →