Intracellular protein transmembrane transport

Across TCGA patient cohorts, RNA activity of the Intracellular protein transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COA3, ZKSCAN1, and PHRF1_S814, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular protein transmembrane transport activity versus COA3 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COA3 →	+0.211	+0.029	.004	.002	3	5
HNSC	ZKSCAN1 →	+0.415	+0.074	<.001	.001	3	5
LSCC	PHRF1_S814 →	-0.482	-0.047	<.001	<.001	3	5
GBM	TMOD3 →	-0.226	-0.029	.003	.008	3	4
GBM	UCHL1 →	+0.413	+0.028	<.001	<.001	3	4
GBM	CASKIN1_S1257 →	+0.516	+0.045	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0065002 vs COA3 — GBM

Explore this scatter interactively →