Intracellular protein transmembrane transport

Across TCGA patient cohorts, RNA activity of the Intracellular protein transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASSF2, RASL12, and THSD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular protein transmembrane transport activity versus RASSF2 in LSCC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RASSF2 →	-0.610	-0.182	.009	.003	3	6
BRCA	RASL12 →	-0.561	-0.191	<.001	<.001	3	6
BRCA	THSD1 →	-0.564	-0.180	<.001	.002	3	6
CCRCC	CMAHP →	-0.469	-0.232	.002	.006	3	6
BRCA	NDN →	-0.927	-0.223	<.001	<.001	3	6
COAD	COLEC12 →	-0.791	-0.226	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0065002 vs RASSF2 — LSCC

Explore this scatter interactively →