Intracellular protein transmembrane transport

Across TCGA cell cohorts, RNA activity of the Intracellular protein transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED9, NID1, and PLBD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular protein transmembrane transport activity versus TMED9 in CNS (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TMED9 →	+0.656	+0.167	.001	.005	3	7
OESOPHAGUS	NID1 →	+2.102	+0.160	.003	.005	3	6
LUNG_SCLC	PLBD2 →	+0.989	+0.217	.001	.001	3	6
LUNG_SCLC	DDOST →	+1.054	+0.219	<.001	<.001	3	6
CNS	FNDC3B →	+0.878	+0.223	.003	.002	2	7
OVARY	ANKRD39 →	-0.958	-0.262	.007	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0065002 vs TMED9 — CNS

Explore this scatter interactively →