Protein localization to postsynapse

Across TCGA patient cohorts, RNA activity of the Protein localization to postsynapse pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAL2, IQANK1, and FBLN7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to postsynapse activity versus MAL2 in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAL2 →	+0.601	+0.832	<.001	<.001	3	5
UCEC	IQANK1 →	+0.675	+0.463	.001	.004	3	5
GBM	FBLN7 →	-0.571	-0.840	.001	<.001	3	4
GBM	ELFN2 →	+0.985	+0.752	<.001	<.001	3	4
GBM	PLEKHG2 →	-0.503	-0.595	<.001	.002	3	4
PDAC	SV2A →	-0.246	-0.513	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062237 vs MAL2 — GBM

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