Protein localization to postsynapse

Across TCGA cell cohorts, RNA activity of the Protein localization to postsynapse pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX264, EXOSC7, and ACAA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to postsynapse activity versus TEX264 in KIDNEY (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TEX264 →	+0.696	+0.232	.003	.004	3	4
URINARY_TRACT	EXOSC7 →	+0.693	+0.268	.002	.001	3	4
BLOOD_Leukemia	ACAA2 →	-1.157	-0.127	.001	.002	3	4
BONE	ARR3 →	-0.234	-0.294	<.001	<.001	3	4
SOFT_TISSUE	CHEK2 →	-0.831	-0.350	.001	.001	3	4
LUNG_SCLC	UQCRC1 →	+0.578	+0.175	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062237 vs TEX264 — KIDNEY

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