Positive regulation of pattern recognition receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of pattern recognition receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5MC1, SELENBP1, and ARHGAP18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of pattern recognition receptor signaling pathway activity versus ATP5MC1 in OESOPHAGUS (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ATP5MC1 →	-1.047	-0.211	.003	.004	2	5
LUNG_NSCLC_LUSC	SELENBP1 →	-4.042	-0.204	<.001	.005	3	4
LUNG_NSCLC_LUSC	ARHGAP18 →	-2.314	-0.193	.007	.006	3	4
URINARY_TRACT	NUP43 →	-0.476	-0.214	.008	.002	3	4
OESOPHAGUS	HADHA →	-0.976	-0.207	.002	.003	3	4
SKIN	SLC35B4 →	-0.804	-0.153	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062208 vs ATP5MC1 — OESOPHAGUS

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