Positive regulation of pattern recognition receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of pattern recognition receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB1, STAT1, and ALDOA, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of pattern recognition receptor signaling pathway activity versus PSMB1 in URINARY_TRACT (Pearson r = -0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PSMB1 →	-1.150	-0.209	.001	.003	2	10
PANCREAS	STAT1 →	-1.105	-0.177	.004	.004	3	8
URINARY_TRACT	ALDOA →	-2.657	-0.209	.001	.003	3	8
LIVER	PSMA6 →	-1.088	-0.224	<.001	<.001	3	8
LIVER	PSMA1 →	-0.937	-0.224	<.001	<.001	3	8
LIVER	UGP2 →	-2.418	-0.285	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062208 vs PSMB1 — URINARY_TRACT

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