Regulation of lysosome size

Across TCGA patient cohorts, RNA activity of the Regulation of lysosome size pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VPS37B, RPS14, and RRM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lysosome size activity versus VPS37B in GBM (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VPS37B →	-0.309	-0.042	<.001	.001	3	6
PDAC	RPS14 →	-0.214	-0.023	.001	<.001	3	4
GBM	RRM1 →	-0.377	-0.042	.002	.002	3	4
OV	TRAF2 →	-0.272	-0.044	.004	.001	3	4
GBM	DHFR →	-0.575	-0.043	.001	.002	3	4
GBM	ELP1 →	-0.169	-0.044	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062196 vs VPS37B — GBM

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