Regulation of lysosome size

Across TCGA patient cohorts, RNA activity of the Regulation of lysosome size pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NINJ2, PSMA6, and SPATA18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lysosome size activity versus NINJ2 in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NINJ2 →	+0.738	+0.244	<.001	<.001	3	4
LUAD	PSMA6 →	-0.479	-0.157	.001	<.001	3	3
LUAD	SPATA18 →	+0.615	+0.101	.005	.002	3	3
CCRCC	ZNF48 →	+0.245	+0.114	.002	.002	3	3
CCRCC	RNU7-127P →	-0.891	-0.133	.004	.002	3	3
COAD	RNU2-5P →	-0.179	-0.942	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062196 vs NINJ2 — BRCA

Explore this scatter interactively →