Regulation of lysosome size

Across TCGA cell cohorts, RNA activity of the Regulation of lysosome size pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-G, RUNX2, and PORCN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HLA-G grouped by Regulation of lysosome size-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HLA-G →	+0.563	+1.140	.001	<.001	3	4
OVARY	RUNX2 →	+1.464	+0.987	.001	.001	3	4
BLOOD_Lymphoma	PORCN →	+3.059	+0.477	.002	.002	3	4
BLOOD_Lymphoma	RNF217 →	+2.145	+0.562	<.001	.009	3	4
BLOOD_Lymphoma	RYK →	+1.348	+0.477	.002	.002	3	4
BLOOD_Lymphoma	ZNF774 →	+0.885	+0.477	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HLA-G by Regulation of lysosome size activity — CNS

Explore this box plot interactively →