Regulation of lysosome size

Across TCGA cell cohorts, RNA activity of the Regulation of lysosome size pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPD2, RCBTB1, and TNFAIP8L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lysosome size activity versus GPD2 in KIDNEY (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GPD2 →	+1.296	+0.397	.002	.005	3	4
KIDNEY	RCBTB1 →	+0.845	+0.420	.007	.002	3	4
CNS	TNFAIP8L1 →	+0.447	+0.333	.007	.004	3	4
LARGE_INTESTINE	CD163L1 →	-1.854	-0.241	<.001	.004	2	5
BREAST	ADCK1 →	+0.847	+0.457	.001	<.001	3	4
LUNG_SCLC	CD300LF →	-0.111	-0.761	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062196 vs GPD2 — KIDNEY

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