Zinc ion import into organelle

Across TCGA cell cohorts, RNA activity of the Zinc ion import into organelle pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC30A7, SLC30A1, and PDZD4, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zinc ion import into organelle activity versus SLC30A7 in BLOOD_Myeloma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SLC30A7 →	+1.282	+0.117	<.001	<.001	3	13
OVARY	SLC30A1 →	+0.976	+0.111	<.001	.001	3	11
LUNG_SCLC	PDZD4 →	-2.129	-0.100	.006	<.001	3	11
PANCREAS	TMED5 →	+1.170	+0.115	<.001	.002	3	9
BONE	SELENOF →	+0.774	+0.122	.002	.003	3	8
BLOOD_Leukemia	C22orf39 →	-0.447	-0.068	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062111 vs SLC30A7 — BLOOD_Myeloma

Explore this scatter interactively →