Zinc ion import into organelle

Across TCGA cell cohorts, RNA activity of the Zinc ion import into organelle pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCGF3, DIP2C, and IPP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zinc ion import into organelle activity versus PCGF3 in CNS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PCGF3 →	+0.571	+1.326	.002	<.001	3	5
LARGE_INTESTINE	DIP2C →	+1.311	+1.038	<.001	<.001	3	5
OVARY	IPP →	+1.138	+1.382	<.001	.004	3	4
BREAST	TACO1 →	+0.698	+0.854	.002	.007	3	4
LARGE_INTESTINE	PRRC1 →	+0.890	+1.336	<.001	<.001	3	3
SKIN	ASAH1 →	+2.058	+1.149	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062111 vs PCGF3 — CNS

Explore this scatter interactively →