Positive regulation of programmed necrotic cell death

Across TCGA cell cohorts, RNA activity of the Positive regulation of programmed necrotic cell death pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, DDB2, and RPS27L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Positive regulation of programmed necrotic cell death-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDKN1A →	-2.830	-1.437	<.001	<.001	3	8
LUNG_NSCLC_LUAD	DDB2 →	-1.338	-0.617	<.001	.008	3	8
SKIN	RPS27L →	-1.326	-1.812	<.001	<.001	3	8
KIDNEY	MDM2 →	-1.847	-1.658	.002	.001	3	7
LUNG_NSCLC_LUAD	FDXR →	-1.237	-0.601	<.001	.007	3	6
SOFT_TISSUE	TNFRSF10B →	-0.952	-1.451	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Positive regulation of programmed necrotic cell death activity — SKIN

Explore this box plot interactively →