Negative regulation of programmed necrotic cell death

Across TCGA patient cohorts, RNA activity of the Negative regulation of programmed necrotic cell death pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOLC1, NKRF, and OLFML1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of programmed necrotic cell death activity versus NOLC1 in GBM (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NOLC1 →	-0.335	-0.074	<.001	<.001	3	7
LSCC	NKRF →	-0.343	-0.048	<.001	.001	3	6
UCEC	OLFML1 →	+0.886	+0.075	<.001	.002	3	6
LSCC	PSMB10 →	+0.491	+0.086	<.001	<.001	3	6
LSCC	SRRM2_S424 →	-0.413	-0.068	.002	<.001	3	6
LSCC	SYNPO_S623 →	+0.624	+0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062099 vs NOLC1 — GBM

Explore this scatter interactively →