Negative regulation of programmed necrotic cell death

Across TCGA cell cohorts, RNA activity of the Negative regulation of programmed necrotic cell death pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LURAP1L, CYBRD1, and DUSP16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LURAP1L grouped by Negative regulation of programmed necrotic cell death-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LURAP1L →	-1.950	-1.320	.005	<.001	3	5
BREAST	CYBRD1 →	-1.858	-0.713	.001	.006	3	4
BLOOD_Leukemia	DUSP16 →	+0.903	+0.954	.003	.001	3	4
BLOOD_Myeloma	LEPR →	-1.570	-1.678	.003	.002	3	4
OVARY	IL10RB →	-1.349	-1.039	.004	.007	3	4
OESOPHAGUS	AFF4 →	-0.908	-1.042	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LURAP1L by Negative regulation of programmed necrotic cell death activity — STOMACH

Explore this box plot interactively →