Negative regulation of programmed necrotic cell death

Across TCGA cell cohorts, RNA activity of the Negative regulation of programmed necrotic cell death pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFA10, MS4A14, and PARM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFA10 grouped by Negative regulation of programmed necrotic cell death-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NDUFA10 →	-0.433	-1.386	<.001	.001	3	4
LUNG_NSCLC_LUAD	MS4A14 →	-0.146	-1.199	.003	<.001	3	3
SKIN	PARM1 →	+0.207	+0.872	.007	.006	3	3
LUNG_NSCLC_LUAD	LRRC75A →	-0.164	-1.036	.004	.004	3	3
BREAST	RCN2 →	+0.275	+1.131	<.001	<.001	3	3
BREAST	STAM →	-0.193	-0.739	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFA10 by Negative regulation of programmed necrotic cell death activity — LARGE_INTESTINE

Explore this box plot interactively →