Negative regulation of programmed necrotic cell death

Across TCGA cell cohorts, RNA activity of the Negative regulation of programmed necrotic cell death pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP24, FRMD6, and IL7R, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of programmed necrotic cell death activity versus ARHGAP24 in SOFT_TISSUE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ARHGAP24 →	+2.592	+1.313	<.001	.002	3	7
SOFT_TISSUE	FRMD6 →	+5.015	+2.045	.002	<.001	3	7
SOFT_TISSUE	IL7R →	+4.199	+1.660	<.001	<.001	3	7
BREAST	TJP3 →	-2.951	-1.494	<.001	<.001	3	6
LIVER	FOSL1 →	+4.384	+1.559	<.001	<.001	3	6
BREAST	NT5E →	+3.533	+1.502	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062099 vs ARHGAP24 — SOFT_TISSUE

Explore this scatter interactively →