Regulation of programmed necrotic cell death

Across TCGA patient cohorts, RNA activity of the Regulation of programmed necrotic cell death pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM21, SLC12A7_S997, and PARP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of programmed necrotic cell death activity versus TRIM21 in LSCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM21 →	+0.321	+0.060	<.001	<.001	3	8
HNSC	SLC12A7_S997 →	+0.746	+0.070	.005	.001	3	7
GBM	PARP4 →	+0.432	+0.052	<.001	<.001	3	7
HNSC	UBA7 →	+0.408	+0.057	<.001	<.001	2	7
UCEC	SHFL →	+0.252	+0.060	.001	.008	3	6
LSCC	IL16 →	+0.653	+0.075	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062098 vs TRIM21 — LSCC

Explore this scatter interactively →