Regulation of programmed necrotic cell death

Across TCGA patient cohorts, RNA activity of the Regulation of programmed necrotic cell death pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAPLN3, CD4, and RAPGEFL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of programmed necrotic cell death activity versus HAPLN3 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HAPLN3 →	+1.006	+0.185	.006	.005	3	5
HNSC	CD4 →	+0.920	+0.133	<.001	.002	3	4
LSCC	RAPGEFL1 →	-1.241	-0.218	<.001	<.001	3	4
LSCC	SLC15A3 →	+0.676	+0.207	<.001	.001	3	4
OV	PERP →	-1.039	-0.219	.005	.002	3	4
LSCC	C2orf42 →	-0.341	-0.184	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062098 vs HAPLN3 — UCEC

Explore this scatter interactively →