Regulation of programmed necrotic cell death

Across TCGA cell cohorts, RNA activity of the Regulation of programmed necrotic cell death pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCBD1, ZNF439, and ZNF491, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of programmed necrotic cell death activity versus PCBD1 in BLOOD_Leukemia (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCBD1 →	-1.400	-0.188	.002	<.001	3	5
BLOOD_Lymphoma	ZNF439 →	+1.915	+0.201	<.001	.002	3	4
BLOOD_Leukemia	ZNF491 →	+0.744	+0.184	.009	.005	3	4
BLOOD_Lymphoma	ZNF493 →	+1.696	+0.195	<.001	.008	3	4
BREAST	AFTPH →	-0.531	-0.219	.005	.004	3	4
BLOOD_Leukemia	ZFP82 →	+1.022	+0.177	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062098 vs PCBD1 — BLOOD_Leukemia

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