Regulation of cardiac epithelial to mesenchymal transition

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATF3, L1CAM, and PLA2G4A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac epithelial to mesenchymal transition activity versus ATF3 in BREAST (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATF3 →	-2.069	-2.002	.001	<.001	3	4
OVARY	L1CAM →	-4.663	-1.215	<.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	PLA2G4A →	+1.902	+1.499	.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	N4BP2L1 →	-1.180	-1.523	.009	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	BORCS7 →	-1.113	-1.638	.004	.005	3	3
UPPER_AERODIGESTIVE_TRACT	ATOH7 →	-0.162	-1.998	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062042 vs ATF3 — BREAST

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