Positive regulation of mitotic sister chromatid segregation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INCENP, E2F8, and SSRP1, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic sister chromatid segregation activity versus INCENP in DLBC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	INCENP →	+1.295	+0.099	<.001	<.001	3	28
THYM	E2F8 →	+1.841	+0.157	<.001	<.001	3	26
ACC	SSRP1 →	+1.261	+0.105	<.001	<.001	3	26
LUAD	CENPI →	+1.029	+0.107	<.001	<.001	3	25
THYM	FOXM1 →	+1.877	+0.164	<.001	<.001	3	25
MESO	BRCA1 →	+0.992	+0.108	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062033 vs INCENP — DLBC

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