Positive regulation of mitotic sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED6, ADPRM, and ARNT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED6 grouped by Positive regulation of mitotic sister chromatid segregation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MED6 →	+1.223	+0.208	.002	.004	3	5
BLOOD_Lymphoma	ADPRM →	-1.262	-0.298	.008	<.001	3	4
CNS	ARNT2 →	-1.951	-0.211	<.001	<.001	3	4
LARGE_INTESTINE	LSM2 →	-0.441	-0.154	.006	.004	3	4
BREAST	DLST →	+0.431	+0.162	.001	.003	3	4
LUNG_NSCLC_LUAD	MYO5A →	-0.680	-0.130	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED6 by Positive regulation of mitotic sister chromatid segregation activity — UPPER_AERODIGESTIVE_TRACT

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