Positive regulation of mitotic sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAR1B, CBX5, and PPP3CB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic sister chromatid segregation activity versus SAR1B in BONE (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SAR1B →	-1.144	-0.270	<.001	.001	3	4
OVARY	CBX5 →	+0.914	+0.199	.008	.003	3	4
BREAST	PPP3CB →	+0.948	+0.292	<.001	<.001	3	4
BLOOD_Lymphoma	MMS19 →	+0.542	+0.199	.004	.002	3	4
LUNG_NSCLC_LUAD	SLC22A4 →	-0.938	-0.357	<.001	.007	3	4
LUNG_NSCLC_LUAD	LEMD3 →	+0.454	+0.313	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062033 vs SAR1B — BONE

Explore this scatter interactively →