Regulation of stress granule assembly

Across TCGA patient cohorts, RNA activity of the Regulation of stress granule assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHBDL1, KIRREL1, and MST1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stress granule assembly activity versus RHBDL1 in CCRCC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RHBDL1 →	+0.643	+0.156	.002	<.001	3	4
LUAD	KIRREL1 →	-0.581	-0.166	.001	<.001	3	4
PDAC	MST1L →	-0.515	-0.117	.007	.001	3	4
CCRCC	GSS →	+0.435	+0.172	<.001	<.001	3	3
CCRCC	EARS2 →	+0.329	+0.148	.005	.001	3	3
CCRCC	C1orf198 →	-0.627	-0.133	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062028 vs RHBDL1 — CCRCC

Explore this scatter interactively →