Regulation of stress granule assembly

Across TCGA cell cohorts, RNA activity of the Regulation of stress granule assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC50, UBE2J1, and PALLD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC50 grouped by Regulation of stress granule assembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CCDC50 →	-0.548	-0.898	.005	.004	3	4
OVARY	UBE2J1 →	-0.687	-0.914	.007	.001	3	4
LUNG_NSCLC_LUAD	PALLD →	-1.451	-0.829	.001	.003	3	3
URINARY_TRACT	SWSAP1 →	+0.906	+1.928	.007	<.001	3	3
CNS	FHOD3 →	-1.412	-0.921	<.001	.001	3	3
CNS	NUS1 →	-0.559	-0.788	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC50 by Regulation of stress granule assembly activity — PANCREAS

Explore this box plot interactively →