Regulation of stress granule assembly

Across TCGA cell cohorts, RNA activity of the Regulation of stress granule assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOB1, HNRNPA1, and KARS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stress granule assembly activity versus NOB1 in OVARY (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NOB1 →	+1.263	+0.373	<.001	.001	2	9
OVARY	HNRNPA1 →	+0.961	+0.419	<.001	<.001	3	8
LUNG_SCLC	KARS1 →	+0.661	+0.224	.001	.008	2	8
LUNG_SCLC	USP10 →	+0.688	+0.335	.001	.001	3	7
LUNG_SCLC	RPL13 →	+1.413	+0.368	<.001	<.001	3	6
STOMACH	RPS2 →	+0.839	+0.339	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062028 vs NOB1 — OVARY

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