Negative regulation of small molecule metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of small molecule metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCOR1, ZNF433-AS1, and NSA2P6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of small molecule metabolic process activity versus NCOR1 in GBM (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCOR1 →	+0.264	+0.132	<.001	<.001	3	4
GBM	ZNF433-AS1 →	+0.376	+0.114	<.001	.002	3	4
PDAC	NSA2P6 →	+0.307	+0.186	.001	<.001	3	4
LSCC	DDX17 →	+0.285	+0.141	.002	.004	3	4
LSCC	RNA5SP309 →	+0.699	+0.142	.001	.001	3	4
PDAC	RANBP3 →	+0.161	+0.135	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062014 vs NCOR1 — GBM

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