Negative regulation of small molecule metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of small molecule metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL2, PPL, and DLG5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of small molecule metabolic process activity versus GRHL2 in LUNG_NSCLC_LUAD (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GRHL2 →	-1.578	-0.127	.008	.003	3	6
STOMACH	PPL →	-3.244	-0.330	.001	.003	3	6
SKIN	DLG5 →	-0.741	-0.216	<.001	<.001	3	5
SKIN	NHS →	-1.230	-0.257	<.001	.003	3	5
BREAST	LSR →	-1.329	-0.137	.001	.008	3	5
STOMACH	EXPH5 →	-1.596	-0.250	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062014 vs GRHL2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →