Secondary palate development

Across TCGA patient cohorts, RNA activity of the Secondary palate development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMB1, ARHGEF17, and SBSPON, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secondary palate development activity versus LAMB1 in OV (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAMB1 →	+0.535	+0.050	<.001	<.001	3	9
UCEC	ARHGEF17 →	+0.478	+0.089	<.001	<.001	3	9
UCEC	SBSPON →	+0.897	+0.070	<.001	.002	3	8
BRCA	RSU1 →	+0.352	+0.045	<.001	<.001	3	8
OV	CAVIN1 →	+0.606	+0.053	<.001	<.001	3	8
UCEC	CNRIP1 →	+0.569	+0.051	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062009 vs LAMB1 — OV

Explore this scatter interactively →