Secondary palate development

Across TCGA cell cohorts, RNA activity of the Secondary palate development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1, NCAPH2, and GTPBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secondary palate development activity versus ITGB1 in LUNG_SCLC (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ITGB1 →	-1.285	-1.348	.006	.003	3	6
BLOOD_Leukemia	NCAPH2 →	+0.720	+0.995	.003	<.001	3	4
LUNG_SCLC	GTPBP1 →	+1.008	+1.136	<.001	.001	3	4
BLOOD_Leukemia	SIVA1 →	+1.190	+1.088	<.001	.001	3	3
LUNG_NSCLC_LUAD	DTWD1 →	+0.855	+0.519	<.001	.001	3	3
SOFT_TISSUE	OXSM →	+0.494	+0.561	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062009 vs ITGB1 — LUNG_SCLC

Explore this scatter interactively →