Meiosis I cell cycle process

Across TCGA patient cohorts, RNA activity of the Meiosis I cell cycle process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLK1, RRM2, and KIF18B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiosis I cell cycle process activity versus PLK1 in BRCA (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLK1 →	+0.899	+0.734	<.001	<.001	3	9
GBM	RRM2 →	+1.204	+0.968	<.001	<.001	3	9
BRCA	KIF18B →	+1.153	+0.760	<.001	<.001	3	9
GBM	RAD54L →	+0.993	+1.152	<.001	<.001	3	9
OV	FAM72C →	+0.593	+0.242	<.001	.005	3	9
LUAD	GINS1 →	+1.006	+0.832	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061982 vs PLK1 — BRCA

Explore this scatter interactively →