Meiosis I cell cycle process

Across TCGA cell cohorts, RNA activity of the Meiosis I cell cycle process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELL, TMEM183A, and LONRF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELL grouped by Meiosis I cell cycle process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ELL →	+0.668	+0.185	<.001	.006	3	5
SOFT_TISSUE	TMEM183A →	+0.740	+0.281	.002	.003	3	4
LUNG_NSCLC_LUAD	LONRF1 →	-0.590	-0.124	.005	.006	2	5
SOFT_TISSUE	DNAJC6 →	+1.164	+0.276	.001	<.001	3	3
SOFT_TISSUE	MED14 →	+0.521	+0.258	.006	.002	3	3
LUNG_SCLC	SAP30BP →	+0.548	+0.219	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELL by Meiosis I cell cycle process activity — LUNG_SCLC

Explore this box plot interactively →