Articular cartilage development

Across TCGA patient cohorts, RNA activity of the Articular cartilage development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, SVIL_S549, and TAGLN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Articular cartilage development activity versus KANK2 in UCEC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KANK2 →	+0.586	+0.090	<.001	<.001	3	9
UCEC	SVIL_S549 →	+1.329	+0.158	<.001	<.001	3	8
OV	TAGLN →	+1.130	+0.123	<.001	<.001	3	8
UCEC	TPM2 →	+1.091	+0.130	<.001	<.001	3	8
BRCA	HSPG2 →	+0.419	+0.045	<.001	<.001	3	8
OV	KANK2_S375 →	+0.612	+0.089	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061975 vs KANK2 — UCEC

Explore this scatter interactively →