Establishment of left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Establishment of left/right asymmetry pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAPS, RPGR_S961, and SPA17, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of left/right asymmetry activity versus CAPS in GBM (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CAPS →	+1.117	+0.095	<.001	.001	3	7
UCEC	RPGR_S961 →	+0.761	+0.268	<.001	<.001	3	6
UCEC	SPA17 →	+1.082	+0.270	<.001	<.001	3	6
UCEC	TPPP3 →	+1.977	+0.315	<.001	<.001	3	6
UCEC	WDR19 →	+0.490	+0.297	<.001	<.001	3	6
UCEC	WDR35 →	+0.501	+0.286	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061966 vs CAPS — GBM

Explore this scatter interactively →