Establishment of left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Establishment of left/right asymmetry pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCRIB_S1353, SNTB2_S389, and ACTN4_S507, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of left/right asymmetry activity versus SCRIB_S1353 in LSCC (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SCRIB_S1353 →	+1.406	+1.098	<.001	<.001	3	3
OV	SNTB2_S389 →	-1.608	-0.310	<.001	<.001	3	2
GBM	ACTN4_S507 →	+1.248	+0.226	<.001	<.001	3	2
OV	CUL9_S947 →	-1.136	-0.235	<.001	.005	3	2
UCEC	FERMT2_S351 →	+1.526	+1.379	<.001	<.001	3	2
OV	GAB2_S281 →	+0.766	+0.274	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061966 vs SCRIB_S1353 — LSCC

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