Establishment of left/right asymmetry

Across TCGA cell cohorts, RNA activity of the Establishment of left/right asymmetry pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP52, UMPS, and PDZD9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFAP52 grouped by Establishment of left/right asymmetry-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CFAP52 →	-0.309	-1.682	.008	<.001	3	8
LUNG_NSCLC_LUAD	UMPS →	-0.207	-1.200	<.001	.003	3	4
STOMACH	PDZD9 →	-0.300	-1.511	.004	.001	3	4
SOFT_TISSUE	PSMA8 →	-0.134	-1.514	.003	.004	3	3
SOFT_TISSUE	ZNF829 →	-0.348	-1.968	.004	<.001	3	3
SOFT_TISSUE	RAPGEF3 →	-0.265	-1.494	.002	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFAP52 by Establishment of left/right asymmetry activity — KIDNEY

Explore this box plot interactively →