Establishment of left/right asymmetry

Across TCGA cell cohorts, RNA activity of the Establishment of left/right asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED26, GTPBP1, and DUSP6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED26 grouped by Establishment of left/right asymmetry-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MED26 →	-0.605	-1.648	.001	<.001	2	5
BREAST	GTPBP1 →	-0.854	-0.838	.001	.008	3	3
BREAST	DUSP6 →	+1.629	+0.773	.001	.003	3	3
BREAST	TMCO3 →	-0.843	-0.885	.002	.004	3	3
BREAST	MGAT4B →	-0.710	-0.992	.002	.004	3	3
BREAST	PROM1 →	-2.128	-0.952	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED26 by Establishment of left/right asymmetry activity — STOMACH

Explore this box plot interactively →